Yasunori Okada Selected Research

Disintegrins

1/2020	Expression and Function of a Disintegrin and Metalloproteinases in Cancer-Associated Fibroblasts of Colorectal Cancer.
11/2018	Selective Inhibition of ADAM28 Suppresses Lung Carcinoma Cell Growth and Metastasis.
6/2018	SOX4, an epithelial-mesenchymal transition inducer, transactivates ADAM28 gene expression and co-localizes with ADAM28 at the invasive front of human breast and lung carcinomas.
4/2017	The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice.
10/2016	Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer.
3/2016	Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation.
1/2016	ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q-induced cell death.
1/2016	Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).
11/2013	Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells.
6/2012	Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.

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Yasunori Okada Research Topics

Disease

52	Neoplasms (Cancer) 01/2022 - 01/2002
28	Carcinoma (Carcinomatosis) 11/2018 - 07/2002
22	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2002
13	Inflammation (Inflammations) 01/2020 - 02/2004
7	Osteoarthritis 11/2021 - 07/2004
7	Emphysema 07/2019 - 01/2003
7	Breast Neoplasms (Breast Cancer) 02/2016 - 06/2003
7	Rheumatoid Arthritis 08/2010 - 07/2003
6	Infections 11/2021 - 07/2010
6	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 01/2003
6	Renal Cell Carcinoma (Grawitz Tumor) 10/2020 - 09/2006
6	Aneurysm (Aneurysms) 01/2015 - 07/2009
5	Knee Osteoarthritis 01/2022 - 12/2017
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2018 - 01/2006
5	Fibrosis (Cirrhosis) 01/2015 - 01/2005
4	Arthritis (Polyarthritis) 01/2020 - 02/2008
4	Atherosclerosis 06/2018 - 03/2003
4	Carcinogenesis 07/2015 - 10/2005
4	Abdominal Aortic Aneurysm 05/2012 - 07/2011
4	Hypoxia (Hypoxemia) 04/2007 - 12/2003
4	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) 09/2006 - 09/2003
4	Glioma (Gliomas) 09/2005 - 01/2003
3	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 07/2019 - 09/2016
3	Obesity 04/2017 - 01/2011
3	Lung Neoplasms (Lung Cancer) 01/2017 - 10/2008
3	Disease Progression 01/2015 - 09/2003
3	Diabetic Retinopathy (Retinopathy, Diabetic) 06/2012 - 05/2003
3	Fever (Fevers) 09/2006 - 09/2003
2	Osteophyte 11/2021 - 12/2017
2	Microscopic Polyangiitis 07/2019 - 01/2017
2	Chronic Obstructive Pulmonary Disease (COPD) 06/2018 - 06/2008
2	Pneumonia (Pneumonitis) 06/2018 - 03/2006
2	Necrosis 04/2017 - 07/2011
2	Insulin Resistance 04/2017 - 01/2011
2	Type 2 Diabetes Mellitus (MODY) 04/2017 - 11/2012
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2017 - 11/2012
2	Vasculitis (Vasculitides) 01/2017 - 09/2016
2	Meningeal Carcinomatosis 01/2017 - 01/2016
2	Prostatic Neoplasms (Prostate Cancer) 10/2016 - 03/2012
2	Aortic Dissection 02/2015 - 12/2012
2	Rupture 02/2015 - 10/2008
2	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2015 - 08/2010

Drug/Important Bio-Agent (IBA)

35	Matrix Metalloproteinases (MMPs)IBA 06/2018 - 01/2002
25	Metalloproteases (Metalloproteinases)IBA 01/2021 - 02/2003
15	Proteins (Proteins, Gene)FDA Link 04/2017 - 07/2003
14	DisintegrinsIBA 01/2020 - 07/2004
12	EnzymesIBA 09/2016 - 01/2003
9	Biological ProductsIBA 01/2020 - 01/2003
8	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2020 - 09/2002
8	Messenger RNA (mRNA)IBA 02/2018 - 11/2004
7	CytokinesIBA 01/2022 - 09/2003
6	Hyaluronic Acid (Hyaluronan)IBA 11/2021 - 12/2003
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2021 - 01/2011
6	Matrix Metalloproteinase 14 (MT1-MMP)IBA 05/2007 - 01/2002
5	SmokeIBA 06/2018 - 07/2005
5	Small Interfering RNA (siRNA)IBA 04/2017 - 12/2010
5	CollagenIBA 01/2013 - 01/2003
5	Peptide Hydrolases (Proteases)FDA Link 12/2011 - 01/2005
4	Cadherins (E-Cadherin)IBA 01/2017 - 08/2008
4	heparanaseIBA 09/2016 - 08/2004
4	LigandsIBA 02/2016 - 07/2003
4	Matrix Metalloproteinase 9 (Gelatinase B)IBA 12/2012 - 06/2008
4	Collagenases (Collagenase)FDA Link 12/2010 - 01/2003
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 07/2010
3	Hyaluronan ReceptorsIBA 11/2021 - 04/2013
3	Indicators and Reagents (Reagents)IBA 01/2020 - 10/2008
3	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 07/2019 - 09/2016
3	ThrombospondinsIBA 01/2016 - 07/2004
3	Aggrecans (Aggrecan)IBA 01/2016 - 07/2004
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2015 - 09/2003
3	Matrix Metalloproteinase 13IBA 01/2013 - 03/2007
3	EndotoxinsIBA 05/2012 - 07/2004
3	GelatinasesIBA 01/2010 - 01/2003
3	Matrix Metalloproteinase InhibitorsIBA 01/2010 - 07/2002
3	Tissue Inhibitor of Metalloproteinase-1IBA 07/2009 - 02/2003
3	Monoclonal AntibodiesIBA 10/2008 - 12/2003
3	C-Reactive ProteinIBA 09/2006 - 09/2003
3	Proteoglycans (Proteoglycan)IBA 09/2005 - 06/2003
3	progelatinaseIBA 04/2004 - 06/2003
2	Interleukin-6 (Interleukin 6)IBA 11/2021 - 02/2015
2	Carrier Proteins (Binding Protein)IBA 11/2021 - 07/2013
2	SilverIBA 11/2021 - 03/2016
2	Tyrosine Kinase InhibitorsIBA 10/2020 - 01/2017
2	Peroxidase (Myeloperoxidase)IBA 07/2019 - 03/2006
2	von Willebrand FactorIBA 11/2018 - 06/2012
2	Protein Isoforms (Isoforms)IBA 02/2018 - 10/2005
2	Glucose (Dextrose)FDA LinkGeneric 04/2017 - 01/2011
2	Sunitinib (Sutent)FDA Link 01/2017 - 04/2015
2	osimertinibIBA 01/2017 - 01/2016
2	IntegrinsIBA 04/2016 - 07/2003
2	Dextran SulfateIBA 03/2016 - 04/2009
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 02/2016 - 07/2003
2	aggrecanaseIBA 01/2016 - 07/2006
2	Epidermal Growth Factor (EGF)IBA 12/2015 - 11/2004
2	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 07/2015 - 02/2010
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 02/2015 - 02/2009
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2014 - 02/2012

Therapy/Procedure

12	Therapeutics 01/2021 - 08/2003
2	Injections 11/2021 - 11/2013
2	Remission Induction 07/2019 - 01/2017